Article
Residues Y429 and Y463 of the human CD5 are targeted by protein tyrosine kinases.
European journal of immunology - 1 Apr 2001
Vilà J M, Gimferrer I, Padilla O, Arman M, Places L, Simarro M, Vives J, Lozano F
Abstract excerpt
The human CD5 lymphocyte cell surface co-receptor modulates activation and differentiation responses mediated by the antigen-specific receptor of T and B cells. CD5 is phosphorylated following lymphocyte activation; however, the exact sites and kinases involved are yet to be determined. Jurkat T cell transfectants expressing tyrosine-mutated CD5 molecules have been used to show that residues Y429 and Y463 are...
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