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Article

Tetracycline-controlled expression but not toxicity of an attenuated diphtheria toxin mutant.

Life sciences - 1 Jan 1999

Keyvani K, Baur I, Paulus W

Abstract excerpt

Tight transcriptional regulation of transferred bacterial toxin genes represents a potential approach for gene therapy of cancer. We have previously shown that the gene for wild type diphtheria toxin A chain (DT-A) placed under transcriptional control of a tetracycline-responsive promoter cannot be silenced due to its extreme toxicity. We now have explored a tetracycline-regulated DT-A mutant involving the...

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PMID: 10353625
DOI: 10.1016/s0024-3205(99)00109-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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