Article
Genetic ablation in transgenic mice with an attenuated diphtheria toxin A gene.
Molecular and cellular biology - 1 Feb 1990
Breitman M L, Rombola H, Maxwell I H, Klintworth G K, Bernstein A
Abstract excerpt
We have previously generated microphthalmic mice lacking lens fiber cells by targeting the expression of the diphtheria toxin A (DT-A) gene in transgenic mice with regulatory sequences associated with the mouse gamma 2-crystallin gene. Because of the extreme toxicity of DT to animal cells and the...
Topics
- Animals
- Anophthalmos
- Blotting, Southern
- Cataract
- Crosses, Genetic
- Crystallins
- Diphtheria Toxin
- Genes
- Genes, Bacterial
- Genotype
- Mice
- Mice, Inbred Strains
- Mice, Transgenic
- Restriction Mapping