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Article

Genetic ablation in transgenic mice with an attenuated diphtheria toxin A gene.

Molecular and cellular biology - 1 Feb 1990

Breitman M L, Rombola H, Maxwell I H, Klintworth G K, Bernstein A

Abstract excerpt

We have previously generated microphthalmic mice lacking lens fiber cells by targeting the expression of the diphtheria toxin A (DT-A) gene in transgenic mice with regulatory sequences associated with the mouse gamma 2-crystallin gene. Because of the extreme toxicity of DT to animal cells and the potential leakiness of many tissue-specific regulatory regions, we investigated whether there might be an experimental...

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Identifiers

PMID: 2300048
DOI: 10.1128/mcb.10.2.474-479.1990
PMCID: PMC360817

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