Article
Expression of the PEBP2alphaA/AML3/CBFA1 gene is regulated by BMP4/7 heterodimer and its overexpression suppresses type I collagen and osteocalcin gene expression in osteoblastic and nonosteoblastic mesenchymal cells.
Bone - 1 Feb 1998
Tsuji K, Ito Y, Noda M
Abstract excerpt
PEBP2alphaA/AML3/CBFA1 is one of the transcription regulators that belong to the PEBP2/AML family. The knockout mice, where the gene encoding PEBP2alphaA/AML3/CBFA1 was inactivated, showed no osteogenesis, indicating the critical role of this transcription factor in osteoblastic differentiation (...
Topics
- 3T3 Cells
- Animals
- Blotting, Northern
- Bone Morphogenetic Protein 4
- Bone Morphogenetic Protein 7
- Bone Morphogenetic Proteins
- Collagen
- Core Binding Factor Alpha 1 Subunit
- DNA-Binding Proteins
- Gene Expression Regulation
- Mesoderm
- Mice
- Neoplasm Proteins
- Osteoblasts
- Osteocalcin
- Osteopontin
- Phenotype
- RNA, Messenger