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Article

Growth and differentiation proceeds normally in cells deficient in the immediate early gene NGFI-A.

The Journal of biological chemistry - 28 Apr 1995

Lee S L, Tourtellotte L C, Wesselschmidt R L, Milbrandt J

Abstract excerpt

NGFI-A (also known as EGR-1, zif/268, and Krox-24) is a zinc finger transcription factor induced in many cell types by a variety of growth and differentiation stimuli. To determine if NGFI-A plays a requisite role in these processes, we used homologous recombination to mutate both alleles of NGFI-A in embryonic stem (ES) cells and examined its effect on growth and differentiation. We find that ES cells lacking...

Topics

Animals
Cell Differentiation
Cell Division
Cell Line
DNA-Binding Proteins
Early Growth Response Protein 1
Genes, Immediate-Early
Homozygote
Immediate-Early Proteins
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Recombination, Genetic

Transcription Factors

Source

Identifiers

PMID: 7730380
DOI: 10.1074/jbc.270.17.9971

Genes

EGR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7730380-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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