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Article

NGF administration is associated with increased GnRH immunoreactivity and a GnRH-associated phenotype in hypothalamic NSCs of aging mice.

Frontiers in endocrinology - 1 Jan 2026

Luo Jiao, Jiang Junhai, Zhang Tiantian, Zhang Xiaohua, Huang Yadong, Zhang Xintao, Wang Yulong, Yang Yan

Abstract excerpt

Purpose: Age-related decline in testosterone is closely associated with hypothalamic gonadotropin-releasing hormone (GnRH) neuron dysfunction. Nerve growth factor (NGF) has emerging roles in reproductive system. However, its effect on the differentiation of hypothalamic neural stem cells (htNSCs) into GnRH-associated phenotype remains unexplored. Methods: Male senescence-accelerated mouse P8 (SAMP8) models of...

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Identifiers

PMID: 42109713
DOI: 10.3389/fendo.2026.1736356
PMCID: PMC13153049

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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