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Article

The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice.

The Journal of clinical investigation - 1 Sept 2006

Ismat Fraz A, Xu Junwang, Lu Min Min, Epstein Jonathan A

Abstract excerpt

Neurofibromatosis type I (NF1; also known as von Recklinghausen's disease) is a common autosomal-dominant condition primarily affecting neural crest-derived tissues. The disease gene, NF1, encodes neurofibromin, a protein of over 2,800 amino acids that contains a 216-amino acid domain with Ras-GTPase-activating protein (Ras-GAP) activity. Potential therapies for NF1 currently in development and being tested in...

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Identifiers

PMID: 16906226
DOI: 10.1172/JCI28341
PMCID: PMC1533876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice.PMID 16906226Read ↗

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