Article
Multiple pituitary and ovarian defects in Krox-24 (NGFI-A, Egr-1)-targeted mice.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 1998
Topilko P, Schneider-Maunoury S, Levi G, Trembleau A, Gourdji D, Driancourt M A, Rao C V, Charnay P
Abstract excerpt
The zinc finger transcription factor Krox-24 (NGFI-A, Egr-1) is encoded by an immediate-early serum response gene expressed in various physiological situations and tissues. To investigate its function, we have created a null allele. Mice homozygous for the mutation have a reduced body size, and b...
Topics
- Animals
- Body Constitution
- DNA-Binding Proteins
- Early Growth Response Protein 1
- Female
- Gene Expression Regulation
- Gene Targeting
- Genitalia, Female
- Genitalia, Male
- Growth Hormone
- Homozygote
- Immediate-Early Proteins
- Infertility
- Luteinizing Hormone
- Male
- Mice
- Mice, Knockout
- Ovary