Article
Multiple pituitary and ovarian defects in Krox-24 (NGFI-A, Egr-1)-targeted mice.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 1998
Topilko P, Schneider-Maunoury S, Levi G, Trembleau A, Gourdji D, Driancourt M A, Rao C V, Charnay P
Abstract excerpt
The zinc finger transcription factor Krox-24 (NGFI-A, Egr-1) is encoded by an immediate-early serum response gene expressed in various physiological situations and tissues. To investigate its function, we have created a null allele. Mice homozygous for the mutation have a reduced body size, and both males and females are sterile. These phenotypes were related to defects in the anterior pituitary of both sexes and...
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