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Article

Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons.

Neuron - 22 May 2008

Wickramasinghe S Rasika, Alvania Rebecca S, Ramanan Narendrakumar, Wood John N, Mandai Kenji, Ginty David D

Abstract excerpt

Serum response factor (SRF) is a prototypic transcription factor that mediates stimulus-dependent gene expression. Here, we show that SRF mediates NGF signaling, axonal growth, branching, and target innervation by embryonic DRG sensory neurons. Conditional deletion of the murine SRF gene in DRGs results in no deficits in neuronal viability or differentiation but causes defects in extension and arborization of...

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Source

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Identifiers

PMID: 18498735
DOI: 10.1016/j.neuron.2008.03.006
PMCID: PMC2689374

Genes

NGF
SRF
MAL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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