Article
Identification of a human CD8+ T lymphocyte neo-epitope created by a ras codon 12 mutation which is restricted by the HLA-A2 allele.
Cellular immunology - 1 Aug 1998
Bergmann-Leitner E S, Kantor J A, Shupert W L, Schlom J, Abrams S I
Abstract excerpt
Point mutations in the ras proto-oncogenes, notably at codon 12, are found in high frequency of human malignancies and, thus, may be appropriate targets for the induction of tumor-specific T cell responses in cancer immunotherapy. In this study, we examined the mutant ras protein sequence reflect...
Topics
- Alleles
- Codon
- Epitopes, T-Lymphocyte
- Genes, ras
- HLA-A2 Antigen
- Humans
- Peptide Fragments
- Point Mutation
- T-Lymphocytes, Cytotoxic
- ras Proteins