Article
Memory T cells of a patient with follicular thyroid carcinoma recognize peptides derived from mutated p21 ras (Gln-->Leu61).
International immunology - 1 Nov 1992
Gedde-Dahl T, Spurkland A, Eriksen J A, Thorsby E, Gaudernack G
Abstract excerpt
Point mutations in ras genes resulting in substitutions of amino acid Gly in positions 12 and 13, and Gln in position 61 of the ras gene product p21, are commonly found in human tumors. Peptides derived from aberrant p21 may elicit a tumor specific T cell response, provided that these peptides can bind to HLA molecules of the tumor and the patient has T cells able to recognize the corresponding peptide-HLA...
Topics
- Adenocarcinoma
- Amino Acid Sequence
- Antigens, Neoplasm
- CD4-Positive T-Lymphocytes
- Codon
- Epitopes
- Genes, ras
- HLA-D Antigens
- Humans
- Immunologic Memory
- Immunologic Surveillance