Naturally occurring T-cell response against mutated p21 ras oncoprotein in pancreatic cancer.

doi:10.1158/1078-0432.CCR-05-1672

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Article

Naturally occurring T-cell response against mutated p21 ras oncoprotein in pancreatic cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2006

Kubuschok Boris, Neumann Frank, Breit Rainer, Sester Martina, Schormann Claudia, Wagner Claudia, Sester Urban, Hartmann Frank, Wagner Mathias, Remberger Klaus, Schilling Martin, Pfreundschuh Michael

Abstract excerpt

Mutated p21 ras proteins (muRas) are present in approximately 90% of pancreatic adenocarcinomas and express mutants which can function as cancer-specific antigens. To evaluate the frequency and magnitude of the natural T-cell response against muRas in 19 HLA-A2-positive patients with muRas-positive pancreatic carcinomas, antigen-experienced T lymphocytes in fresh peripheral blood mononuclear cells were shown by...

Topics

Adenocarcinoma
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Cell Line, Tumor
Cross Reactions
Cytotoxicity Tests, Immunologic
Cytotoxicity, Immunologic
DNA Mutational Analysis
Enzyme-Linked Immunosorbent Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Flow Cytometry

HLA-A2 Antigen

Humans

Male

Middle Aged

Mutation

Oncogene Protein p21(ras)

Pancreatic Neoplasms

Source

Open in PubMed

Identifiers

PMID: 16489095
DOI: 10.1158/1078-0432.CCR-05-1672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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