Article
Mutations in residue 61 of H-Ras p21 protein influence MHC class II presentation.
International immunology - 1 Feb 1995
Ngo-Giang-Huong N, Kayibanda M, Deprez B, Levy J P, Guillet J G, Tilkin A F
Abstract excerpt
We have investigated the influence of mutations in the Ras 61 codon on the immunogenicity of synthetic peptides and H-Ras p21 proteins. H-2k mice produced Th responses when immunized with mutated peptides in which the Gln at position 61 in the wild type sequence was replaced by Leu (L) or His (H)...
Topics
- Amino Acid Sequence
- Animals
- Antigen Presentation
- Cell Adhesion
- Cell Line
- Histocompatibility Antigens Class II
- Mice
- Mice, Inbred Strains
- Molecular Sequence Data
- Mutation
- Proto-Oncogene Proteins p21(ras)
- T-Lymphocytes, Helper-Inducer
- Vaccines, Synthetic