Article
No evidence for mutations in a putative beta-cell ATP-sensitive K+ channel subunit in MODY, NIDDM, or GDM.
Diabetes - 1 May 1995
Zhang Y, Warren-Perry M, Sakura H, Adelman J, Stoffel M, Bell G I, Ashcroft F M, Turner R C
Abstract excerpt
The beta-cell ATP-sensitive K+ (K-ATP) channel has a major role in glucose-induced insulin secretion. Screening the entire coding sequence of the gene for a putative beta-cell K-ATP channel subunit, K-ATP2, with single-strand conformation polymorphism did not show any mutations associated with diabetes in white Caucasian diabetic patients, including five pedigrees with maturity onset diabetes of the young (MODY),...
Topics
- Adenosine Triphosphate
- Adult
- Alleles
- Diabetes Mellitus, Type 2
- Diabetes, Gestational
- Female
- Gene Frequency
- Genetic Linkage
- Humans
- Islets of Langerhans
- Male