Article
Lack of association of the Ala(45)Thr polymorphism and other common variants of the NeuroD gene with type 1 diabetes.
Diabetes - 1 Apr 2004
Vella Adrian, Howson Joanna M M, Barratt Bryan J, Twells Rebecca C J, Rance Helen E, Nutland Sarah, Tuomilehto-Wolf Eva, Tuomilehto Jaakko, Undlien Dag E, Rønningen Kjersti S, Guja Cristian, Ionescu-Tîrgovişte Constantin, Savage David A, Todd John A
Abstract excerpt
Variation in genes necessary for normal functioning and development of beta-cells, e.g., NEUROD1, which encodes a transcription factor for the insulin gene and is important in beta-cell development, causes maturity-onset diabetes of the young. Some studies have reported an association between a nonsynonymous Ala(45)Thr (+182G-->A) single nucleotide polymorphism (SNP) in NEUROD1 and type 1 diabetes, but this...
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