Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The beta cell glucokinase promoter variant is an unlikely risk factor for diabetes mellitus. Diabetes Incidence Study in Sweden (DISS).

Diabetologia - 1 Aug 1997

Lotfi K, Sund G, Lowe R, Graham J, Landin-Olsson M, Kockum I, Deeb S, Lernmark A

Abstract excerpt

Glucokinase plays an important role in the regulation of insulin secretion and is therefore an attractive candidate gene for both insulin dependent (IDDM) and non-insulin-dependent (NIDDM) diabetes mellitus. A single G-A nucleotide polymorphism at the -30 position of the beta-cell specific promoter region of the glucokinase gene was previously associated with reduced beta-cell function. In the present study we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Alleles
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Primers

Share to Gene Frequency

Share to Polymerase Chain Reaction

Share to Promoter Regions, Genetic

Share to Risk Factors

Source

Identifiers

PMID: 9267992
DOI: 10.1007/s001250050774

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The beta cell glucokinase promoter variant is an unlikely risk factor for diabetes mellitus. Diabetes Incidence Study in Sweden (DISS).PMID 9267992Read ↗

The g/a nucleotide variant at position -30 in the beta-cell-specific glucokinase gene promoter has no impact on the beta-cell function in Danish Caucasians.Semantic proximity Read ↗

Glucokinase gene islet promoter region variant (G-->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns.Semantic proximity Read ↗

Analysis of the glucokinase gene promoter in Japanese subjects with noninsulin-dependent diabetes mellitus.Semantic proximity Read ↗

Glucokinase gene variants in subjects with late-onset NIDDM and impaired glucose tolerance.Semantic proximity Read ↗

Glucokinase gene in gestational diabetes mellitus: population association study and molecular scanning.Semantic proximity Read ↗

Clinical characteristics of Japanese men with glucokinase gene beta-cell promoter variant.Semantic proximity Read ↗

A variation at position -30 of the beta-cell glucokinase gene promoter is associated with reduced beta-cell function in middle-aged Japanese-American men.Semantic proximity Read ↗

Glucokinase gene variations in Japanese-Americans with a family history of NIDDM.Semantic proximity Read ↗

A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites.Semantic proximity Read ↗

Homozygosity for a common polymorphism in the islet-specific promoter of the glucokinase gene is associated with a reduced early insulin response to oral glucose in pregnant women.Semantic proximity Read ↗

G(-30)A polymorphism in the pancreatic promoter of the glucokinase gene associated with angiographic coronary artery disease and type 2 diabetes mellitus.Semantic proximity Read ↗

Glucokinase gene variants in the common form of NIDDM.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.