Article
The beta cell glucokinase promoter variant is an unlikely risk factor for diabetes mellitus. Diabetes Incidence Study in Sweden (DISS).
Diabetologia - 1 Aug 1997
Lotfi K, Sund G, Lowe R, Graham J, Landin-Olsson M, Kockum I, Deeb S, Lernmark A
Abstract excerpt
Glucokinase plays an important role in the regulation of insulin secretion and is therefore an attractive candidate gene for both insulin dependent (IDDM) and non-insulin-dependent (NIDDM) diabetes mellitus. A single G-A nucleotide polymorphism at the -30 position of the beta-cell specific promot...
Topics
- Adolescent
- Adult
- Alleles
- Base Sequence
- DNA Primers
- Diabetes Mellitus
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Gene Frequency
- Glucokinase
- Humans
- Islets of Langerhans
- Logistic Models
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational