Article
No evidence for mutations in a putative subunit of the beta-cell ATP-sensitive potassium channel (K-ATP channel) in Japanese NIDDM patients.
Biochemical and biophysical research communications - 26 Jun 1995
Yasuda K, Sakura H, Mori Y, Iwamoto K, Shimokawa K, Kadowaki H, Hagura R, Akanuma Y, Adelman J P, Yazaki Y
Abstract excerpt
The ATP-sensitive K channel (K-ATP channel) in pancreatic beta cells is believed to play a crucial role in glucose-stimulated insulin release. We investigated whether defects in the recently cloned gene for a putative subunit of this channel (KATP-2) could be a cause of diabetes in Japanese patie...
Topics
- Adult
- Asian People
- Base Sequence
- DNA Primers
- Diabetes Mellitus, Type 2
- Humans
- Islets of Langerhans
- Japan
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction