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Article

Effect of sequence context on Polζ-dependent error-prone extension past (6-4) photoproducts.

DNA repair - 1 Mar 2020

Akagi Jun-Ichi, Hashimoto Keiji, Suzuki Kenji, Yokoi Masayuki, de Wind Niels, Iwai Shigenori, Ohmori Haruo, Moriya Masaaki, Hanaoka Fumio

Abstract excerpt

The (6-4) pyrimidine-pyrimidone photoproduct [(6-4)PP] is a major DNA lesion induced by ultraviolet radiation. (6-4)PP induces complex mutations opposite its downstream bases, in addition to opposite 3' or 5' base, as has been observed through a site-specific translesion DNA synthesis (TLS) assay. The mechanism by which these mutations occur is not well understood. To elucidate the mechanisms underlying...

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Identifiers

PMID: 31911268
DOI: 10.1016/j.dnarep.2019.102771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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