Article
Rejection of tumors in mice with severe combined immunodeficiency syndrome determined by the major histocompatibility complex. Class I expression on the graft.
Cancer research - 1 May 1995
Glas R, Waldenström M, Höglund P, Klein G, Kärre K, Ljunggren H G
Abstract excerpt
This study addresses the role of MHC class I molecules in the rejection of tumor grafts by SCID mice. Tumor cell lines, their corresponding MHC class I transfectants, and MHC class I-deficient mutants were inoculated to SCID mice. This allowed a study of tumor rejection responses in an environmen...
Topics
- Animals
- Antigens, Neoplasm
- B-Lymphocytes
- G(M1) Ganglioside
- Graft Rejection
- HLA-A2 Antigen
- Histocompatibility Antigens Class I
- Killer Cells, Natural
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Mice, SCID
- Mutation
- Neoplasm Transplantation
- Neoplasms, Experimental
- Severe Combined Immunodeficiency
- T-Lymphocytes
- Transfection