CD4-CD8- T cell receptor alpha beta T cells: generation of an in vitro major histocompatibility complex class I specific cytotoxic T lymphocyte response and allogeneic tumor rejection.

doi:10.1084/jem.174.1.193

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Article

CD4-CD8- T cell receptor alpha beta T cells: generation of an in vitro major histocompatibility complex class I specific cytotoxic T lymphocyte response and allogeneic tumor rejection.

The Journal of experimental medicine - 1 Jul 1991

Mieno M, Suto R, Obata Y, Udono H, Takahashi T, Shiku H, Nakayama E

Abstract excerpt

The generation of an in vitro major histocompatibility complex class I specific response of CD4-CD8- T cell receptor (TCR) alpha beta cytotoxic T lymphocytes (CTL) and their allogeneic tumor rejection were investigated. Inocula of BALBRL male 1 were rejected in C57BL/6 (B6) mice treated with minimum essential medium (MEM) (control), anti-L3T4 (CD4) monoclonal antibody (mAb) or anti-Lyt-2.2 (CD8) mAb and CTL...

Topics

Animals
Antibodies, Monoclonal
Antigens, Differentiation, T-Lymphocyte
Blotting, Northern
CD4 Antigens
CD8 Antigens
Genes, MHC Class I
Graft Rejection
Histocompatibility Antigens Class I
Immunotherapy, Adoptive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia, Experimental

Leukemia, Radiation-Induced

Mice

Mice, Inbred Strains

Neoplasm Transplantation

Phenotype

RNA, Messenger

Receptors, Antigen, T-Cell

Source

Open in PubMed Open full text

Identifiers

PMID: 1905338
DOI: 10.1084/jem.174.1.193
PMCID: PMC2118895

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1905338-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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