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The role of CDKN2A/B deletions in pediatric acute lymphoblastic leukemia

16 Nov 2016

Abstract excerpt

The CDKN2A/B genes in the 9p21 chromosomal region are frequently involved in human cancer, including pediatric acute lymphoblastic leukemia (ALL). These genes encode 3 proteins that belong to the RB1 and TP53 pathways and act as tumor suppressors by regulating the G1/S checkpoint of the cell cycle. The prognostic value of deletions in the CDKN2A/B locus in ALL is controversial in part due to the limitations of...

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PMID: 27960642
DOI: 10.1080/08880018.2016.1251518

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