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Article

Acetylation polymorphism of caffeine in a Japanese population.

Clinical pharmacology and therapeutics - 1 Sept 1992

Hashiguchi M, Ebihara A

Abstract excerpt

The frequency distribution of N-acetylation of caffeine was determined in 140 unrelated healthy Japanese subjects by measuring the amount of two main metabolites of caffeine, 5-acetylamino-6-formyl-amino-3-methyluracil (AFMU) and 1-methylxanthine (1X), in urine after an oral dose of caffeine. N-Acetylation capacity for caffeine appeared to be polymorphic: 15 subjects (10.7%) were phenotyped as slow acetylators,...

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Source

Identifiers

PMID: 1526084
DOI: 10.1038/clpt.1992.141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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