Segregation analyses of four urinary caffeine metabolite ratios implicated in the determination of human acetylation phenotypes.

doi:10.1002/gepi.1370110203

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Article

Segregation analyses of four urinary caffeine metabolite ratios implicated in the determination of human acetylation phenotypes.

Genetic epidemiology - 1 Jan 1994

Vincent-Viry M, Pontes Z B, Gueguen R, Galteau M M, Siest G

Abstract excerpt

Human acetylation phenotypes were determined with caffeine (137X) as the test substance, improved by measuring urinary caffeine metabolites with a previously described HPLC method. Caffeine, 5-acetylamino-6-formylamino-3-methyluracil (AFMU), 1-methylxanthine (IX), 1-methyluric acid (IU), 1,7-dimethylxanthine (17X), and 1,7-dimethyluric acid (17U) were quantified. This study tested the hypothesis, suggested by...

Topics

Acetylation
Adolescent
Adult
Alleles
Arylamine N-Acetyltransferase
Caffeine
Child
Chromatography, High Pressure Liquid
Family
Female
Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Recessive

Humans

Male

Middle Aged

Models, Genetic

Models, Statistical

Phenotype

Source

Open in PubMed

Identifiers

PMID: 8013893
DOI: 10.1002/gepi.1370110203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8013893-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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