Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epstein-Barr Virus Essential Antigen EBNA3C Attenuates H2AX Expression

16 Jan 2014

Abstract excerpt

Epstein-Barr virus (EBV) latent antigen EBNA3C is implicated in B-cell immortalization and linked to several B-cell malignancies. Deregulation of H2AX can induce genomic instability with increased chromosomal aberrations, which ultimately leads to tumorigenesis. Here we demonstrated that EBNA3C can attenuate H2AX expression at the transcript and protein levels. A reduction of total H2AX levels was clearly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Polyomavirus and related diseases
Share to Viral-associated cancers and disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24429368
DOI: 10.1128/jvi.03568-13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epstein-Barr Virus Essential Antigen EBNA3C Attenuates H2AX ExpressionPMID 24429368Read ↗

Epstein-Barr Virus Nuclear Antigen 3C Augments Mdm2-Mediated p53 Ubiquitination and Degradation by Deubiquitinating Mdm2Semantic proximity Read ↗

Impact of EBV Essential Nuclear Protein EBNA-3C on B-Cell Proliferation and ApoptosisSemantic proximity Read ↗

The Cooperative Functions of the EBNA3 Proteins Are Central to EBV Persistence and LatencySemantic proximity Read ↗

Epstein-Barr Virus Nuclear Antigen 3C Facilitates Cell Proliferation by Regulating Cyclin D2Semantic proximity Read ↗

EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors.Semantic proximity Read ↗

Epstein-Barr Virus Nuclear Antigen 3C Interacts with and Enhances the Stability of the c-Myc OncoproteinSemantic proximity Read ↗

EBNA3C Augments Pim-1 Mediated Phosphorylation and Degradation of p21 to Promote B-Cell ProliferationSemantic proximity Read ↗

A study of the Epstein Barr virus nuclear antigens EBNA3A and EBNA3C in vitro and in vivoSemantic proximity Read ↗

Transcriptional and epigenetic modulation of autophagy promotes EBV oncoprotein EBNA3C induced B-cell survivalSemantic proximity Read ↗

An EBNA3C-deleted Epstein-Barr virus (EBV) mutant causes B-cell lymphomas with delayed onset in a cord blood-humanized mouse modelSemantic proximity Read ↗

Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase.Semantic proximity Read ↗

EBNA-3B- and EBNA-3C-Regulated Cellular Genes in Epstein-Barr Virus-Immortalized Lymphoblastoid Cell LinesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.