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Increased association between Epstein-Barr virus EBNA2 from type 2 strains and the transcriptional repressor BS69 restricts EBNA2 activity

8 Jul 2019

Abstract excerpt

Natural variation separates Epstein-Barr virus (EBV) into type 1 and type 2 strains.Type 2 EBV is less transforming in vitro due to sequence differences in the EBV transcription factor EBNA2.This correlates with reduced activation of the EBV oncogene LMP1 and some cell genes.Transcriptional activation by type 1 EBNA2 can be suppressed through the binding of two PXLXP motifs in its transactivation domain (TAD) to...

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PMID: 31283782
DOI: 10.1371/journal.ppat.1007458

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