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Article

Unique behavioural phenotypes of recombinant-inbred CXBK mice: partial deficiency of sensitivity to mu- and kappa-agonists.

Neuroscience research - 1 Aug 1999

Ikeda K, Ichikawa T, Kobayashi T, Kumanishi T, Oike S, Yano R

Abstract excerpt

Recombinant-inbred CXBK mice have been used for various studies as putative mu-opioid-receptor deficient mice. However, CXBK mice have never been compared with gene-targeting mice lacking the mu-opioid receptor (muKO) and the K-opioid receptor (kappaKO). Here we report that CXBK mice show distinct behavioural phenotype in opioid-induced analgesia and sedation. Intraperitoneal (i.p.) administration of morphine (3...

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Source

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PMID: 10515257
DOI: 10.1016/s0168-0102(99)00047-4

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