Article
Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome).
Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 1995
Hyman B T, West H L, Rebeck G W, Buldyrev S V, Mantegna R N, Ukleja M, Havlin S, Stanley H E
Abstract excerpt
The discovery that the epsilon 4 allele of the apolipoprotein E (apoE) gene is a putative risk factor for Alzheimer disease (AD) in the general population has highlighted the role of genetic influences in this extremely common and disabling illness. It has long been recognized that another geneti...
Topics
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Amyloid beta-Peptides
- Apolipoproteins E
- Brain
- Dementia
- Down Syndrome
- Genotype
- Humans
- Image Processing, Computer-Assisted
- Immunohistochemistry