Gender differences in the phenotypic expression of Alzheimer's disease in Down's syndrome (trisomy 21).

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Article

Gender differences in the phenotypic expression of Alzheimer's disease in Down's syndrome (trisomy 21).

Neuroreport - 27 Jun 1994

Raghavan R, Khin-Nu C, Brown A G, Day K A, Tyrer S P, Ince P G, Perry E K, Perry R H

Abstract excerpt

Twenty-eight individuals with typical Down's syndrome (DS) phenotype (17 males and 11 females; age range: 10-74 years) were investigated for gender differences in the phenotypic expression of Alzheimer-type pathology (ATP). Quantitative neuropathology was performed in the 4 neocortical lobes of the right hemisphere, by counting senile plaques (SP), and neurofibrillary tangles (NFT). ATP was present in 25...

Topics

Adenosine Triphosphate
Adolescent
Adult
Age of Onset
Aged
Alzheimer Disease
Brain
Child
Down Syndrome
Female
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Neurofibrillary Tangles

Phenotype

Prospective Studies

Seizures

Sex Factors

Source

Open in PubMed

Identifiers

PMID: 7919207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7919207-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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