Article

Genetic dissection of Down syndrome-associated alterations in APP/amyloid-β biology using mouse models

2020-06-20

Abstract excerpt

Individuals who have Down syndrome (caused by trisomy of chromosome 21), have a greatly elevated risk of early-onset Alzheimer’s disease, in which amyloid-β accumulates in the brain. Amyloid-β is a product of the chromosome 21 gene APP (amyloid precursor protein) and the extra copy or ‘dose’ of APP is thought to be the cause of this early-onset Alzheimer’s disease. However, other chromosome 21 genes likely modul...

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Literature Corpus work: 5e51f40c-7ba0-58fb-8981-a5f42de2ae45
DOI: 10.1101/2020.06.19.162115

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