Article
Stable size distribution of amyloid plaques over the course of Alzheimer disease.
Journal of neuropathology and experimental neurology - 1 Aug 2012
Serrano-Pozo Alberto, Mielke Matthew L, Muzitansky Alona, Gómez-Isla Teresa, Growdon John H, Bacskai Brian J, Betensky Rebecca A, Frosch Matthew P, Hyman Bradley T
Abstract excerpt
Amyloid β plaques are a key pathologic feature of Alzheimer disease (AD), but whether plaque sizes increase or stabilize over the course of AD is unknown. We measured the size distribution of total immunoreactive (10D5-positive) and dense-core (Thioflavin S-positive) plaques in the temporal neocortex of a large group of subjects with AD and age-matched plaque-bearing subjects without dementia to test the...
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