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Article

Neuropathological changes in Down's syndrome hippocampal formation. Effect of age and apolipoprotein E genotype.

Archives of neurology - 1 Apr 1995

Hyman B T, West H L, Rebeck G W, Lai F, Mann D M

Abstract excerpt

BACKGROUND: The neuropathological changes of Alzheimer's disease occur universally in individuals with Down's syndrome as they reach middle age and worsen with increasing age. Thus, evaluation of patients of various ages with Down's syndrome allows one to construct a life history of the development of neuropathological changes associated with Alzheimer's disease at various points in the disease process. METHODS:...

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Identifiers

PMID: 7710373
DOI: 10.1001/archneur.1995.00540280059019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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