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Article

Neuropathological changes in Down's syndrome hippocampal formation. Effect of age and apolipoprotein E genotype.

Archives of neurology - 1 Apr 1995

Hyman B T, West H L, Rebeck G W, Lai F, Mann D M

Abstract excerpt

BACKGROUND: The neuropathological changes of Alzheimer's disease occur universally in individuals with Down's syndrome as they reach middle age and worsen with increasing age. Thus, evaluation of patients of various ages with Down's syndrome allows one to construct a life history of the developme...

Topics

Adolescent
Adult
Aging
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Child
Child, Preschool
Dementia
Down Syndrome
Female
Genotype
Hippocampus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Middle Aged

Neurofibrillary Tangles

Source

Identifiers

PMID: 7710373
DOI: 10.1001/archneur.1995.00540280059019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7710373-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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