Article

Endosomal structure and APP biology are not altered in preclinical cellular models of Down syndrome

2021-12-30

Abstract excerpt

Individuals who have Down syndrome (trisomy 21) are at greatly increased risk of developing Alzheimer’s disease – dementia. Alzheimer’s disease is characterised by the accumulation in the brain of amyloid-β plaques that are a product of amyloid precursor protein, encoded by the APP gene on chromosome 21. In Down syndrome the first site of amyloid-β accumulation is within endosomes and changes to endosome biology...

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Literature Corpus work: a3c3bc06-54ad-5507-aa55-6360faffb0ae
DOI: 10.1101/2021.12.30.474570

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