Article
Alterations in N-methyl-D-aspartate receptor binding in dystonic hamster brains.
Brain research - 2 Jan 1997
Nobrega J N, Richter A, Jiwa D, Raymond R, Löscher W
Abstract excerpt
The genetically dystonic hamster is an animal model of idiopathic dystonia that displays sustained abnormal movements and postures either spontaneously or in response to mild environmental stimuli. Previous pharmacological studies have shown that competitive and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists exert potent antidystonic activity in this model, indicating that abnormal NMDA receptor...
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