Article
Functional analysis of a mutant estrogen receptor isolated from T47Dco breast cancer cells.
American journal of obstetrics and gynecology - 1 Apr 1992
Leslie K K, Tasset D M, Horwitz K B
Abstract excerpt
OBJECTIVE: Estrogen receptor-positive cancers that initially respond to hormone therapy often progress to a resistant state. The breast cancer cell line T47Dco is a model for such resistance. It is a polymorphic line, composed of multiple cell populations that demonstrate the presence of mutant estrogen receptors by cloning and sequencing techniques. Our objective was to isolate and analyze the structural and...
Topics
- Base Sequence
- Breast Neoplasms
- DNA
- Female
- Gene Expression
- Gene Library
- Humans
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Receptors, Estrogen
- Tumor Cells, Cultured