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Article

Functional analysis of a mutant estrogen receptor isolated from T47Dco breast cancer cells.

American journal of obstetrics and gynecology - 1 Apr 1992

Leslie K K, Tasset D M, Horwitz K B

Abstract excerpt

OBJECTIVE: Estrogen receptor-positive cancers that initially respond to hormone therapy often progress to a resistant state. The breast cancer cell line T47Dco is a model for such resistance. It is a polymorphic line, composed of multiple cell populations that demonstrate the presence of mutant estrogen receptors by cloning and sequencing techniques. Our objective was to isolate and analyze the structural and...

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Identifiers

PMID: 1566760
DOI: 10.1016/s0002-9378(11)90590-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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