Article
Genetic differences between BCG substrains.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease - 1 Feb 1995
Zhang Y, Wallace R J, Mazurek G H
Abstract excerpt
SETTING: University-affiliated Mycobacteriology Reference Laboratory. OBJECTIVE: To determine the genetic differences of 25 BCG isolates representing 16 referenced substrains. DESIGN: Non-randomized, observational study based on the visual comparison of the large restriction fragment (LRF) patterns created by digesting each BCG isolate's DNA with an infrequent cutting restriction endonuclease (DraI, AsnI, XbaI or...
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