Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons.

doi:10.1016/0896-6273(95)90216-3

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons.

Neuron - 1 Apr 1995

Beck K D, Powell-Braxton L, Widmer H R, Valverde J, Hefti F

Abstract excerpt

Homozygous Igf1-/- mice at 2 months of age had reduced brain weights, with reductions evenly affecting all major brain areas. The gross morphology of the CNS was normal, but the size of white matter structures in brain and spinal cord was strongly reduced, owing to decreased numbers of axons and...

Topics

Animals
Astrocytes
Axons
Brain
Calbindin 2
Calbindins
Cell Count
Corpus Striatum
Glial Fibrillary Acidic Protein
Hippocampus
Insulin-Like Growth Factor I
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Mutation

Myelin Sheath

Neurons

Organ Size

Parvalbumins

Source

Open in PubMed

Identifiers

PMID: 7718235
DOI: 10.1016/0896-6273(95)90216-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7718235-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons.PMID 7718235Read ↗

Mutant mouse models of insulin-like growth factor actions in the central nervous system.Semantic proximity Read ↗

Adulthood Deficiency of the Insulin-like Growth Factor-1 Receptor in Hippocampal Neurons Impairs Cell Structure and Spatial Learning and Memory in Male and Not Female MiceSemantic proximity Read ↗

Brain growth retardation due to the expression of human insulin like growth factor binding protein-1 in transgenic mice: an in vivo model for the analysis of igf function in the brain.Semantic proximity Read ↗

Type 1 insulin-like growth factor receptor signaling is essential for the development of the hippocampal formation and dentate gyrus.Semantic proximity Read ↗

Expanding the Mind: Insulin-Like Growth Factor I and Brain DevelopmentSemantic proximity Read ↗

Cochlear abnormalities in insulin-like growth factor-1 mouse mutants.Semantic proximity Read ↗

Insulin-like growth factor (IGF) signaling through type 1 IGF receptor plays an important role in remyelination.Semantic proximity Read ↗

Developmental and oncogenic effects of insulin-like growth factor-I in Ptc1+/- mouse cerebellum.Semantic proximity Read ↗

Delayed inner ear maturation and neuronal loss in postnatal Igf-1-deficient mice.Semantic proximity Read ↗

Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delaySemantic proximity Read ↗

Insulin-like growth factor-I improves cerebellar dysfunction but does not prevent cerebellar neurodegeneration in the calcium channel mutant mouse, leaner.Semantic proximity Read ↗

Phenotypic changes in calbindin D28K immunoreactivity in the hippocampus of Fmr1 knockout mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.