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Article

Insulin-like growth factor (IGF) signaling through type 1 IGF receptor plays an important role in remyelination.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Aug 2003

Mason Jeffrey L, Xuan Shouhong, Dragatsis Ioannis, Efstratiadis Argiris, Goldman James E

Abstract excerpt

We examined the role of IGF signaling in the remyelination process by disrupting the gene encoding the type 1 IGF receptor (IGF1R) specifically in the mouse brain by Cre-mediated recombination and then exposing these mutants and normal siblings to cuprizone. This neurotoxicant induces a demyelinating lesion in the corpus callosum that is reversible on termination of the insult. Acute demyelination and...

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Identifiers

PMID: 12930811
PMCID: PMC6740767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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