Article
Cochlear abnormalities in insulin-like growth factor-1 mouse mutants.
Hearing research - 1 Aug 2002
Camarero Guadalupe, Villar M Angeles, Contreras Julio, Fernández-Moreno Carmen, Pichel José G, Avendaño Carlos, Varela-Nieto Isabel
Abstract excerpt
Insulin-like growth factor 1 (IGF-1) modulates inner ear cell proliferation, differentiation and survival in culture. Its function in human hearing was first evidenced by a report of a boy with a homozygous deletion of the Igf-1 gene, who showed severe sensorineural deafness [Woods et al., New Engl. J. Med. 335 (1996) 1363-1367]. To better understand the in vivo role of IGF-1 during inner ear differentiation and...
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