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Expanding the Mind: Insulin-Like Growth Factor I and Brain Development

7 Aug 2008

Abstract excerpt

Signaling through the type 1 IGF receptor (IGF1R) after interaction with IGF-I is crucial to the normal brain development. Manipulations of the mouse genome leading to changes in the expression of IGF-I or IGF1R significantly alters brain growth, such that IGF-I overexpression leads to brain overgrowth, whereas null mutations in either IGF-I or the IGF1R result in brain growth retardation. IGF-I signaling...

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PMID: 18687773
DOI: 10.1210/en.2008-0920

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