Article
Delayed inner ear maturation and neuronal loss in postnatal Igf-1-deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Oct 2001
Camarero G, Avendano C, Fernandez-Moreno C, Villar A, Contreras J, de Pablo F, Pichel J G, Varela-Nieto I
Abstract excerpt
Insulin-like growth factor-1 (IGF-1) has been shown to play a key role during embryonic and postnatal development of the CNS, but its effect on a sensory organ has not been studied in vivo. Therefore, we examined cochlear growth, differentiation, and maturation in Igf-1 gene knock-out mice at postnatal days 5 (P5), P8, and P20 by using stereological methods and immunohistochemistry. Mutant mice showed reduction...
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