Article
Brain growth retardation due to the expression of human insulin like growth factor binding protein-1 in transgenic mice: an in vivo model for the analysis of igf function in the brain.
Brain research. Developmental brain research - 14 Oct 1994
D'Ercole A J, Dai Z, Xing Y, Boney C, Wilkie M B, Lauder J M, Han V K, Clemmons D R
Abstract excerpt
Three lines of transgenic (Tg) mice carrying a fusion gene linking the mouse metallothionein-I promoter to a cDNA encoding human insulin-like growth factor binding protein-1 (hIGFBP-1) were found to express the transgene in brain. As judged by comparing Tg brain weights to those of non-transgenic littermates, adult hemizygotic Tg mice of each line exhibited brain growth retardation (16.2%, 14.4% and 8.1%...
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