Brain growth retardation due to the expression of human insulin like growth factor binding protein-1 in transgenic mice: an in vivo model for the analysis of igf function in the brain.

doi:10.1016/0165-3806(94)90164-3

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Article

Brain growth retardation due to the expression of human insulin like growth factor binding protein-1 in transgenic mice: an in vivo model for the analysis of igf function in the brain.

Brain research. Developmental brain research - 14 Oct 1994

D'Ercole A J, Dai Z, Xing Y, Boney C, Wilkie M B, Lauder J M, Han V K, Clemmons D R

Abstract excerpt

Three lines of transgenic (Tg) mice carrying a fusion gene linking the mouse metallothionein-I promoter to a cDNA encoding human insulin-like growth factor binding protein-1 (hIGFBP-1) were found to express the transgene in brain. As judged by comparing Tg brain weights to those of non-transgenic...

Topics

Aging
Animals
Base Sequence
Brain
Carrier Proteins
DNA Primers
DNA, Complementary
Female
Gene Expression
Genotype
Humans
Immunohistochemistry
In Situ Hybridization
Insulin-Like Growth Factor Binding Protein 1

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insulin-Like Growth Factor I

Insulin-Like Growth Factor II

Liver

Male

Source

Open in PubMed

Identifiers

PMID: 7531120
DOI: 10.1016/0165-3806(94)90164-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7531120-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.