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Article

Insulin-like growth factor-I improves cerebellar dysfunction but does not prevent cerebellar neurodegeneration in the calcium channel mutant mouse, leaner.

Neurobiology of disease - 1 Nov 2003

Nahm Sang-Soep, Frank Tamy C, Browning Michelle D, Sepulvado Jarita M, Hiney Jill K, Abbott Louise C

Abstract excerpt

The effects of insulin-like growth factor-I (IGF-I) on cerebellar dysfunction and neurodegeneration were investigated in leaner mice, which exhibit cerebellar ataxia and neurodegeneration related to P/Q-type calcium channel mutations. Leaner mice showed significantly reduced serum and cerebellar IGF-I concentrations compared to wild-type mice at postnatal day 30. Behavioral assessment of leaner mice injected with...

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PMID: 14572439
DOI: 10.1016/s0969-9961(03)00106-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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