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Article

Mutant mouse models of insulin-like growth factor actions in the central nervous system.

Neuropeptides - 1 Jan 2000

D'Ercole A Joseph, Ye Ping, O'Kusky John R

Abstract excerpt

Insulin-like growth factor-I (IGF-I) and its cognate receptor, the type 1 IGF receptor (IGF1R), as well as high-affinity IGF binding proteins (IGFBP) that modulate IGF-I actions, are expressed throughout the course of brain development. These observations, taken together with studies in cultured neural cells demonstrating a variety of IGF-I growth-promoting activities, provide a strong argument for IGF-I having a...

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Source

Identifiers

PMID: 12359511
DOI: 10.1054/npep.2002.0893

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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