Article
The hr locus and the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in newborn mice.
Archives of toxicology - 1 Jan 1994
Connor M J, Puhvel S M, Sakamoto M, Nanthur J
Abstract excerpt
In mice, the recessive mutation hairless (hr) controls the cutaneous response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) but its influence on TCDD's systemic toxicity is unclear. To clarify this, we compared the effects of lactational TCDD exposure on standardized litters of newborn HRS/J mice homozygous for either hr or + that were fostered by haired dams exposed to 0, 6, 8 or 12 micrograms TCDD/kg body...
Topics
- Animals
- Animals, Newborn
- Body Weight
- Genotype
- Humans
- Infant, Newborn
- Liver
- Mice
- Mice, Hairless
- Mutation
- Polychlorinated Dibenzodioxins
- Thymus Gland