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Postnatal development of resistance to short-term high-dose toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in TCDD-resistant and -semiresistant rats.

Toxicology and applied pharmacology - 1 Apr 2004

Simanainen Ulla, Tuomisto Jouni T, Pohjanvirta Raimo, Syrjälä Paula, Tuomisto Jouko, Viluksela Matti

Abstract excerpt

Despite great interspecies differences in adult 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) sensitivity, the toxic potency of TCDD is similar across species in fetal mortality. Han/Wistar (Kuopio; H/W) rats are exceptionally resistant to acute toxicity of TCDD, but show sensitivity to embryotoxicity and teratogenicity. The resistance of adult H/W rats to acute TCDD toxicity is based on a point mutation in the...

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Identifiers

PMID: 15050403
DOI: 10.1016/j.taap.2003.11.025

Genes

AHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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