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Article

Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus.

Nature - 4 Apr 2002

Jia Jianhang, Amanai Kazuhito, Wang Gelin, Tang Jiong, Wang Bing, Jiang Jin

Abstract excerpt

The Drosophila protein Shaggy (Sgg, also known as Zeste-white3, Zw3) and its vertebrate orthologue glycogen synthase kinase 3 (GSK3) are inhibitory components of the Wingless (Wg) and Wnt pathways. Here we show that Sgg is also a negative regulator in the Hedgehog (Hh) pathway. In Drosophila, Hh acts both by blocking the proteolytic processing of full-length Cubitus interruptus, Ci (Ci155), to generate a...

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Identifiers

PMID: 11912487
DOI: 10.1038/nature733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus.PMID 11912487Read ↗

Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1.Semantic proximity Read ↗

Regulation of hedgehog Ligand Expression by the N-End Rule Ubiquitin-Protein Ligase Hyperplastic Discs and the Drosophila GSK3β Homologue, Shaggy.Semantic proximity Read ↗

Functional studies of shaggy/glycogen synthase kinase 3 phosphorylation sites in Drosophila melanogaster.Semantic proximity Read ↗

Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.Semantic proximity Read ↗

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb.Semantic proximity Read ↗

G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.Semantic proximity Read ↗

Transcriptional regulation of the Hedgehog effector CI by the zinc-finger gene combgap.Semantic proximity Read ↗

The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms.Semantic proximity Read ↗

Ci: a complex transducer of the hedgehog signal.Semantic proximity Read ↗

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator.Semantic proximity Read ↗

Regulation of wingless signaling by the CKI family in Drosophila limb development.Semantic proximity Read ↗

Genetic evidence for a protein kinase A/cubitus interruptus complex that facilitates processing of cubitus interruptus in Drosophila.Semantic proximity Read ↗

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