Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Segregation analysis of human red blood cell thiopurine methyltransferase activity.

Genetic epidemiology - 1 Jan 1995

Vuchetich J P, Weinshilboum R M, Price R A

Abstract excerpt

Thiopurine methyltransferase (TPMT) catalyzes thiopurine S-methylation, an important metabolic pathway for drugs such as 6-mercaptopurine (6-MP). Inherited differences in the activity of this enzyme are related to individual differences in the therapeutic efficacy and toxicity of 6-MP and other thiopurine drugs. Variation of TPMT activity in the red blood cell (RBC) has been found to reflect activity differences...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Heterozygote
Share to Adolescent
Share to Child

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Genetic Variation

Share to Homozygote

Share to Models, Genetic

Share to Selection, Genetic

Source

Identifiers

PMID: 7713396
DOI: 10.1002/gepi.1370120102

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Segregation analysis of human red blood cell thiopurine methyltransferase activity.PMID 7713396Read ↗

Genetic segregation analysis of red blood cell (RBC) histamine N-methyltransferase (HNMT) activity.Semantic proximity Read ↗

Methylation pharmacogenetics: thiopurine methyltransferase as a model system.Semantic proximity Read ↗

Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity.Semantic proximity Read ↗

Genomewide Approach Validates Thiopurine Methyltransferase Activity Is a Monogenic Pharmacogenomic Trait.Semantic proximity Read ↗

Validation of a high-performance liquid chromatography method for thiopurine S-methyltransferase activity in whole blood using 6-mercaptopurine as substrate.Semantic proximity Read ↗

Thiopurine methyltransferase polymorphic tandem repeat: genotype-phenotype correlation analysis.Semantic proximity Read ↗

Expressing thiopurine S-methyltransferase activity as units per litre of whole-blood overcomes misleading high results in patients with anaemia.Semantic proximity Read ↗

Genotypic and phenotypic analysis of the polymorphic thiopurine S-methyltransferase gene (TPMT) in a European population.Semantic proximity Read ↗

Reference intervals for thiopurine S-methyltransferase activity in red blood cells using 6-thioguanine as substrate and rapid non-extraction liquid chromatography.Semantic proximity Read ↗

Thiopurine S-methyltransferase activity in Japanese subjects: metabolic activity of 6-mercaptopurine 6-methylation in different TPMT genotypes.Semantic proximity Read ↗

Whole-blood thiopurine S-methyltransferase activity with genotype concordance: a new, simplified phenotyping assay.Semantic proximity Read ↗

Thiopurine methyltransferase activity: new conditions for reversed-phase high-performance liquid chromatographic assay without extraction and genotypic-phenotypic correlation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.