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Article

Segregation analysis of human red blood cell thiopurine methyltransferase activity.

Genetic epidemiology - 1 Jan 1995

Vuchetich J P, Weinshilboum R M, Price R A

Abstract excerpt

Thiopurine methyltransferase (TPMT) catalyzes thiopurine S-methylation, an important metabolic pathway for drugs such as 6-mercaptopurine (6-MP). Inherited differences in the activity of this enzyme are related to individual differences in the therapeutic efficacy and toxicity of 6-MP and other thiopurine drugs. Variation of TPMT activity in the red blood cell (RBC) has been found to reflect activity differences...

Topics

Adolescent
Adult
Child
Erythrocytes
Female
Gene Frequency
Genetic Variation
Heterozygote
Homozygote
Humans
Likelihood Functions
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methyltransferases

Middle Aged

Models, Genetic

Selection, Genetic

Source

Identifiers

PMID: 7713396
DOI: 10.1002/gepi.1370120102

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7713396-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Segregation analysis of human red blood cell thiopurine methyltransferase activity.PMID 7713396Read ↗

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Methylation pharmacogenetics: thiopurine methyltransferase as a model system.Semantic proximity Read ↗

Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity.Semantic proximity Read ↗

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