Article
Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity.
Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 1997
Tai H L, Krynetski E Y, Schuetz E G, Yanishevski Y, Evans W E
Abstract excerpt
TPMT is a cytosolic enzyme that catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including medications such as mercaptopurine and thioguanine. TPMT activity exhibits autosomal codominant genetic polymorphism, and patients inheriting TPMT deficiency are at high risk o...
Topics
- Alleles
- Animals
- COS Cells
- Cloning, Molecular
- Endopeptidases
- Erythrocytes
- Humans
- Kinetics
- Methyltransferases
- Polymorphism, Genetic
- Protein Biosynthesis
- Rabbits
- Recombinant Proteins
- Saccharomyces cerevisiae
- Transfection