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Article

Whole-blood thiopurine S-methyltransferase activity with genotype concordance: a new, simplified phenotyping assay.

Annals of clinical biochemistry - 1 Sept 2006

Ford Loretta, Graham Valerie, Berg Jonathan

Abstract excerpt

BACKGROUND: We have developed a new thiopurine S-methyltransferase (TPMT) phenotyping method that measures TPMT activity in whole blood. To evaluate this assay, we compared it with conventional TPMT phenotyping, which uses a red blood cell (RBC) lysate and genotyping for analysis of common TPMT mutations. METHODS: Whole-blood and RBC lysates were prepared from 402 patients' samples received for routine analysis....

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Identifiers

PMID: 17036413
DOI: 10.1258/000456306778520070

Genes

TPMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Whole-blood thiopurine S-methyltransferase activity with genotype concordance: a new, simplified phenotyping assay.PMID 17036413Read ↗

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