Article
Expressing thiopurine S-methyltransferase activity as units per litre of whole-blood overcomes misleading high results in patients with anaemia.
Annals of clinical biochemistry - 1 Sept 2010
Barlow N L, Graham V, Berg J D
Abstract excerpt
BACKGROUND: Thiopurine S-methyltransferase (TPMT) phenotype analysis, expressed as TPMT activity, is established as a routine pharmacogenomic test to screen patients prior to initiating thiopurine drug therapy. Conventionally measured TPMT activity is corrected for red blood cell (RBC) parameters. Here we present evidence that supports the simplification of the TPMT assay: by expressing TPMT activity in mU/L...
Topics
- Anemia
- Blood Chemical Analysis
- False Positive Reactions
- Genotype
- Hemoglobins
- Humans
- Methyltransferases
- Phenotype
- Reference Values
- Reproducibility of Results